Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Trefz, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trefz, B.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Histochemical Investigation of the Modal Specificity of Taste

Bruce Trefz

School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104, USA

The taste mechanism was investigated in a primate (Macaca mulatta). Based on the hypothesis that intracellular enzymes contribute to the transduction of tastes to electric impulses by taste cells, a histochemical survey of the activity of several enzymes was made on taste buds from regions of the mouth associated with sweet, salt, sour, and bitter tastes. Considerable differences were noted among the modalities, which confirmed the hypothesis. An exclusively bitter enzyme was identified.

REFERENCES

  • Loven, O.C.: Bidrag till Kannendomen om tungans smakpapiller, Med Arch (Stockholm) 3(9):1, 1867.
  • Adey, W.R.: The Sense of Smell, in Field, J.; Magoun, H.W.; and Hall, V.E. (eds), Handbook of Physiology, vol I, Washington: American Physiological Society, 1959, p 481.
  • Baradi, A.F., and Bourne, G.H.: Localization of Gustatory and Olfactory Enzymes in the Rabbit, and the Problem of Taste and Smell, Nature (Lond) 168: 977, 1951.[Medline] [Order article via Infotrieve]
  • Nada, O., and Iwayama, T.: Histochemical Observation on the Phosphatase Activities of the Differentiating Taste Bud, Anat Rec 165 (1):61, 1969.[Medline] [Order article via Infotrieve]
  • Defendi, V., and Pearson, B.: Quantitative Estimation of Succinic Dehydrogenase Activity in a Single Microscopic Tissue Section, J Histochem Cytochem 3:61, 1955.[Medline] [Order article via Infotrieve]
  • Farber, E.; Sternberg, W.H.; and Pearce, N.A.M.: Histochemical Localization of Choline Oxidase and D-Amino Acid Oxidase with Tetrazolium Salts and Phenozine Methosulfate, J Histochem Cytochem 6: 389, 1958.
  • Altmann, F.P.: The Cellular Chemistry of Certain Cytoplasmic Oxidative Enzymes and Their Relevance to the Metabolism of Cancers, PhD thesis, University of London, 1968.
  • Biochemists' Handbook, Long, C. (ed), London: Spon, 1961, p 368.
  • Hess, R.: Beta-Hydroxybutyric Dehydrogenase Activity in Tumors, Am J Pathol 37:583, 1960.
  • Burstone, M.S.: The Relationship Between Fixation and Techniques for the Histochemical Localization of Hydrolytic enzymes, J Histochem Cytochem 6:322, 1958.[Medline] [Order article via Infotrieve]
  • Dixon, M., and Webb, E.C.: Enzymes, 2nd ed, London: Longmans, 1964, p 233.
  • Chiquoine, A.D.: The Distribution of Glucose-6-Phosphatase in the Liver and Kidney of the Mouse, J Histochem Cytochem 1: 429, 1953.[Abstract]
  • Wachstein, M., and Meisel, E.: Histochemistry of Substrate-Specific Phosphatases at a Physiological pH, J Histochem Cytochem 4:424, 1956.
  • Novikoff, A., and Goldfischer, S.: Nucleotide Diphosphatase Activity in the Golgi Apparatus, Proc Natl Acad Sci 47: 802, 1961.[Free Full Text]
  • Bourne, G.H.: Alkaline Phosphatase in Taste Buds and Nasal Mucosa, Nature (Lond) 161:444, 1948.
  • Burstone, M.S.: Histochemical Demonstration of Acid Phosphatases with Naphthol AS-Phosphates, J Natl Cancer Inst 19: 523, 1958.
  • Gomori, G.: Microscopic Histochemistry, Principles and Practice, Chicago: University of Chicago Press, 1952, p 193.
  • Pevzner, R.A.: Determination of the Succinic Dehydrogenase Activity in Taste Buds of Some Vertebrate Mammals, Dokl Akad Nauk SSSR 155:191, 1964.[Medline] [Order article via Infotrieve]
  • Baradi, A.F., and Bourne, G.H.: New Observations on the Alkaline Phosphatase Reaction in the Papilla Foliata, J Biophys Biochem Cytol 5:173, 1959.
  • Von Bekesy, G.: The Duplexity Theory of Taste, Science 145:834, 1964.[Abstract/Free Full Text]
  • Farbman, A.I.: Fine Structure of the Taste Bud, J Ultrastruct Res 12:328, 1965.[CrossRef][Medline] [Order article via Infotrieve]
  • Nemetschek-Gansler, H., and Ferner, H.: On the Ultrastructure of the Taste Buds, Z Zellforsch Mikrosk Anat 63:155, 1964.[CrossRef][Medline] [Order article via Infotrieve]
  • Deduve, C.: Lysosomes, a New Group of Cytoplasmic Particles, Hayashi, T. (ed): Subcellular Particles, New York: Ronald, 1959.
  • Danielli, J.F.: Cytochemistry: A Critical Approach, London: Chapman and Hall, 1953, p 81.
  • Farber, E.: Principles of Oxidative Enzyme Histochemistry, in Histochemistry, Kansas City: University of Kansas Press, 1964, p 11.
  • Burstone, M.S.: Histochemical Demonstration of Cytochrome Oxidase with New Amine Reagents, J Histochem Cytochem 8:63, 1960.[Abstract]
  • Altmann, F.P.: The Retention and Estimation of "Soluble" Dehydrogenases in Unfixed Tissue Sections, Biochem J 96:53, 1965.[Medline] [Order article via Infotrieve]
  • Novikoff, A.; Goldfischer, S.; and Essner, E.: The Importance of Fixation in a Cytochemical Method for the Golgi Apparatus, J Histochem Cytochem 9:459, 1961.[Medline] [Order article via Infotrieve]
  • Underhay, E.; Holt, S.J.; Beaufay, H.; and Deduge, C.: Intracellular Localization of Esterase in Rat Liver, J Biophys Biochem Cytol 2:635, 1956.[Medline] [Order article via Infotrieve]
  • West, E.S., and Todd, W.R.: Textbook of Biochemistry, New York: Macmillan, 1961, p 853.
  • Henkin, R.I.; Graziadei, P.P.; and Brad-Ley, B.F.: NIH Clinical Staff Conference: The Molecular Basis of Taste and Its Disorders, Ann Intern Med 71:791, 1969.[Abstract/Free Full Text]
  • Baradi, A.F., and Bourne, G.H.: Theory of Taste and Odors, Science 113:660, 1951.[Free Full Text]

Journal of Dental Research, Vol. 51, No. 5, 1203-1211 (1972)
DOI: 10.1177/00220345720510050601


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Trefz, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trefz, B.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?