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Collagenolysis in Cultured Tissue: I. Digestion of Mesenteric Fibers by Enzymes from Explanted Gingival Tissue

The University of Texas Dental Science Institute at Houston, Houston, Texas 77025, USA

Collagen fibers of cultured rat mesentery were lysed by an enzyme diffusing from explants of gingival tissue in the same culture. The enzyme was nondialyzable, heat labile, and specific for collagen. Its action was facilitated by heparin, vitamin A, and a product of mast cell granules but was inhibited by cortisone and histamine. Gingival cells in prolonged culture lost the capacity to digest collagen.

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Journal of Dental Research, Vol. 50, No. 5, 1294-1300 (1971)
DOI: 10.1177/00220345710500053501


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This article has been cited by other articles:

				G. G. Rose and P. B. Robertson Collagenolysis by Human Gingival Fibroblast Cell Lines Journal of Dental Research, April 1, 1977; 56(4): 416 - 424. [Abstract] [PDF]

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				A. C. Taylor Collagenolysis in Cultured Tissue: II. Role of Mast Cells Journal of Dental Research, September 1, 1971; 50(5): 1301 - 1306. [Abstract] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Taylor, A. C. Search for Related Content PubMed PubMed Citation Articles by Taylor, A. C. Social Bookmarking                         What's this?