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Blood and Urinary Fluoride Levels in Humans Associated with Ingestion of Sodium Fluoride-Containing Vitamin Tablets

Preventive Dentistry Research Institute, Indiana University Medical Center, Indianapolis, Indiana 46202

George K. Stookey

Preventive Dentistry Research Institute, Indiana University Medical Center, Indianapolis, Indiana 46202

Joseph C. Muhler

Preventive Dentistry Research Institute, Indiana University Medical Center, Indianapolis, Indiana 46202

Urine and blood were collected from young adults at predetermined intervals after ingesting 1.0 mg fluoride (as NaF) in a vitamin-fluoride tablet. The urinary fluoride concentration reached a maximum within two hours and returned to the normal value within six hours; blood fluoride changes paralleled those observed in urine.

REFERENCES

• Council on Dental Therapeutics: Accepted Dental Remedies 32nd ed, Chicago: American Dental Association, 1967, pp 161-162.
• Stookey, G.K.: "Fluoride Therapy," in Bernier, J.L., and Muhler, J.C., Improving Dental Practice through Preventive Measures, St. Louis, Mo.: V. V. Mosby Co., 1966, pp 76-132.
• Hennon, D.K.; Stookey, G.K.; and Muhler, J.C.: The Clinical Anticarcinogenic Effectiveness of Supplementary Fluoride-Vitamin Preparations: Results at the End of Three Years, J Dent Child 33:3-12, 1966.[Medline] [Order article via Infotrieve]
• Hennon, D.K.; Stookey, G.K.; and Muhler, J.C.: The Clinical Anticarcinogenic Effectiveness of Supplementary Fluoride-Vitamin Preparations: Results at the End of Four Years, J Dent Child 34:439-443, 1967.[Medline] [Order article via Infotrieve]
• Margolis, F.J.; Macauley, J.; and Freshman, E.: The Effects of Measured Doses of Fluoride: A Five-Year Preliminary Report, Amer J Dis Child 113:670-672, 1967.[Abstract/Free Full Text]
• Margolis, F.J.; Reames, H.R.; Macauley, J.C.; Freshman, E.; and Mehaffey, H.: Practical Aspects in Caries Prevention: A Seven-Year Study, Scientific Exhibit, Wayne State University, School of Medicine, Detroit, Mich, 1968.
• Largent, E.J.: "Metabolism of Inorganic Fluorides," in Shaw, J.H. (ed), Fluoridation as a Public Health Measure. Washington, D.C.: American Association for the Advancement of Science, 1954, pp 49-78.
• Smith, F.A.; Gardner, D.E.; and Hodge, H.C.: Investigations on the Metabolism of Fluoride: II. Fluoride Content of Blood and Urine as a Function of the Fluorine in Drinking Water, J Dent Res 29:596-600, 1950.[Free Full Text]
• Singer, L., and Armstrong, W.D.: Regulation of Human Plasma Fluoride Concentration, J Appl Physiol 15:508-510, 1960.[Abstract/Free Full Text]
• Bixler, D.: Blood and Urinary Studies Using Fluoride Tablets, J Dent Res 39: 1119, 1960.
• Muhler, J.C.; Stookey, G.K.; Spear, L.B.; and Bixler, D.: Blood and Urinary Fluoride Studies Following the Ingestion of Single Dosages of Fluoride, J Oral Ther 2:241-260, 1966.
• McClure, F.J.: "Nondental Physiological Effects of Trace Quantities of Fluoride," in MouLToN, F.R. (ed), Dental Caries and Fluorine, Washington, D.C.: American Association for the Advancement of Science, 1946, p 89.
• Machle, W.; Scott, E.W.; and Largent, E.S.: The Absorption and Excretion of Fluorides: I. The Normal Fluoride Balance, J Indust Hyg & Toxicol 24:199-204, 1942.
• Armstrong, W.D.; Singer, L.; Ensinck, J.; and Rich, C.: Plasma Fluoride Concentrations of Patients Treated with Sodium Fluoride, J Clin Invest 43:555, 1964.[Medline] [Order article via Infotrieve]
• Schweisberger, R., and Muhler, J.C.: Urinary Fluoride Levels in Children Following the Clinical Use of a Stannous Fluoride-Containing Dentifrice, J Dent Res 35:760-762, 1956.[Free Full Text]
• Singer, L., and Armstrong, W.D.; Determination of Fluoride in Blood Serum, Anal Chem 31:105-108, 1959.[Medline] [Order article via Infotrieve]
• McClure, F.J., and Kinser, C.A.: Fluoride Domestic Waters and Systemic Effects: II. Fluorine Content of Urine in Relation to Fluorine in Drinking Water, Public Health Rep 59:1575-1591, 1944.[Medline] [Order article via Infotrieve]
• Zipkin, I.; Likins, R.C.; Mcclure, F.J.; and Steere, A.C.: Urinary Fluoride Levels Associated with the Use of Fluoridated Water, Public Health Rep 71:767-772, 1956.[Medline] [Order article via Infotrieve]
• Hennon, D.K.; Stookey, G.K.; and Muhler, J.C.: Fluoride Excretion with Sodium Fluoride-Vitamin Tablets, J Dent Res 47: 710-716, 1968.[Abstract/Free Full Text]
• Likins, R.C.; Mcclure, F.J.; and Steere, A.C.: Urinary Excretion of Fluoride Following Defluordiation of a Water Supply, Public Health Rep 71:217-220, 1956.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 48, No. 6, 1211-1215 (1969)
DOI: 10.1177/00220345690480062001


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hennon, D. K. Articles by Muhler, J. C. Search for Related Content PubMed PubMed Citation Articles by Hennon, D. K. Articles by Muhler, J. C. Social Bookmarking                         What's this?