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Effect of Alcohol and Cigarette Smoke as Promoting Agents in Hamster Pouch Carcinogenesis

Department of Oral Pathology and Dental Research, School of Dentistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23219

In a series of young Syrian hamsters, pouch carcinogenesis initiated by application of 7, 12-dimethylbenz(a)anthracene (DMBA) to cheek epithelium was augmented by subsequent application of alcohol or applied whole cigarette smoke or both. These findings support previous reports that smoke and alcohol act individually as promoting agents in experimental oral carcinogenesis. Neither locally applied alcohol nor applied whole cigarette smoke acted as co-carcinogens or carcinogens on hamster pouch epithelium. Under conditions of this study, whole cigarette smoke appeared to be a more potent promoting agent than locally applied alcohol, as evaluated clinically and histologically.

REFERENCES

• Goldhaber, P.: The Role of Saliva and Other Local Environmental Factors in Oral Carcinogenesis, JADA 54:517, 1957.[Medline] [Order article via Infotrieve]
• Kreshover, S.J., and Salley, J.J.: Predisposing Factors in Oral Cancer, JADA 54:509, 1957.
• Wynder, E.L.; Bross, I.J.; and Feldman, R.M.: A Study of Etiological Factors in Cancer of the Mouth, Cancer 10:1300, 1957.[CrossRef][Medline] [Order article via Infotrieve]
• Smoking and Health, Report of the Advisory Committee to the Surgeon General of the Public Health Service Washington, DC, 1964.
• Salley, J.J.: Smoking and Oral Cancer, J Dent Res 42:328, 1963.[Free Full Text]
• Elzay, R.P.: Local Effect of Alcohol in Combination with DMBA on Hamster Cheek Pouch, J Dent Res 45:1788, 1966.[Free Full Text]
• Salley, J.J.: Experimental Carcinogenesis in Cheek Pouch of the Syrian Hamster, J Dent Res 33:253, 1954.[Medline] [Order article via Infotrieve]
• Elzay, R.P.: Dimethyl Sulfoxide and Experimental Oral Carcinogenesis in the Hamster Pouch, Arch Path 83:293, 1967.[Medline] [Order article via Infotrieve]
• Kreshover, S.J.: The Effect of Tobacco on Epithelial Tissues of Mice, JADA 45:528, 1952.
• Ketcham, A.S.; Wexler, H.; and Mantel, N.: Effect of Alcohol in Mouse Neoplasia, Cancer Res 23:667, 1963[Abstract/Free Full Text]
• Epstein, S.S.: Carcinogenicity of Organic Extracts of Atmospheric Pollutants, J Air Pollut Contr Ass 17:728, 1967.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 48, No. 6, 1200-1205 (1969)
DOI: 10.1177/00220345690480061801


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Elzay, R. P. Search for Related Content PubMed PubMed Citation Articles by Elzay, R. P. Social Bookmarking                         What's this?