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Development of Caries in the Hunt-Hoppert Caries-Susceptible and Caries-Resistant Rats Under Different Experimental Conditions
Rachel H. Larson
US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland
Paul H. Keyes
US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland
Bette Joan Goss
US Department of Health, Education, and Welfare, Public Health Service, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland
Rats of both Hunt-Hoppert lines, originally designated as caries-susceptible (Ca-S) and caries-resistant (Ca-R) lines, were highly susceptible to caries when subjected to a combination of diet and microflora that provided a challenge to the resistance of all surfaces of the teeth. Strain differences were indicated by the predominance of sulcal lesions in the Ca-S line and smooth-surface lesions in the Ca-R line.
REFERENCES
- Hunt, H.R.; Hoppert, C.A.; and Erwin, W.G.: Inheritance of Susceptibility to Caries in Albino Rats (Mus norvegicus), J Dent Res 23:385-401, 1944.[Free Full Text]
- Stephan, R.M., and Harris, M.R.: "Location of Experimental Caries on Different Tooth Surfaces in the Norway Rat," in R. F. Sognnaes (ed.), Aduances in Experimental Caries Research, Washington, DC: American Association for the Advancement of Science, 1955, pp 47-65.
- Keyes, P.H.: Dental Caries in the Molar Teeth of Rats: I. Distribution of Lesions Induced by High-Carbohydrate, Low-Fat Diets, J Dent Res 37:1077-1087, 1958.
- Rosen, S.; Hunt, H.R.; and Hoppert, C.A.: Hereditary Limitations of the Infectious and Transmissible Nature of Experimental Dental Caries, Arch Oral Biol 5: 92-97, 1961.[CrossRef][Medline]
[Order article via Infotrieve]
- Larson, R.H., and Fitzgerald, R.J.: Caries Development in Rats of Different Ages with Controlled Flora, Arch Oral Biol 9: 705-712, 1964.[CrossRef]
- Rosen, S.; Sreebny, L.M.; Hoppert, C.A.; Hunt, H.R.; and Bachem, E.: Studies on Salivariadenectomized Hunt-Hoppert Caries-Resistant and Osborne-Mendel-Susceptible (OMS) Rats: IV. Effect of Selective Salivariadenectomy on Dental Caries and Several Groups of the Oral Microflora, J Dent Res 38:1166-1172, 1959.[Free Full Text]
- Stephan, RM; Fitzgerald, R.J.; Mc-Clure, F.J.; Harris, M.R.; and Jordan, H.: The Comparative Effects of Penicillin, Bacitracin, Chloromycetin , Aureomycin and Streptomycin on Experimental Dental Caries and on Certain Oral Bacteria in the Rat, J Dent Res 31:421-427, 1952.
- Keyes, P.H., and Jordan, H.V.: Periodontal Lesions in the Syrian Hamster: III. Findings Related to an Infectious and Transmissible Component, Arch Oral Biol 9:377-400, 1964.[CrossRef]
- Keyes, P.H.: Dental Caries in the Molar Teeth of Rats: II. A Method for Diagnosing and Scoring Several Types of Lesions Simultaneously, J Dent Res 37:1088-1099, 1958.[Free Full Text]
- Larson, R.H.; Theilade, E.; and Fitzgerald, R.J.: The Interaction of Diet and Microflora in Experimental Caries in the Rat, Arch Oral Biol 12:563-668, 1967.
- Larson, R.H., and Goss, B.J.: Diet as a Limiting Factor in the Transmissibility of Caries Activity Between Rats of Different Strains, Arch Oral Biol 12:1085-1094, 1967.[CrossRef][Medline]
[Order article via Infotrieve]
- Hoppert, C.A.; Webber, P.A.; and Caniff, T.L.: The Production of Dental Caries in Rats Fed an Adequate Diet, J Dent Res 12:161-173, 1932.[Free Full Text]
- Rosen, S.; Hunt, H.R.; and Hoppert, C.A.: The Importance of the Genotype and Susceptibility to Dental Caries in the Rat, J Dent Res 40:352-354, 1961.[Free Full Text]
- Shaw, J.H., and Griffiths, D.: Evaluation of the Degree of Caries-Susceptibility in Strains of Rats, Arch Oral Biol 3:15-27, 1960.[CrossRef][Medline]
[Order article via Infotrieve]
- Shaw, J.H., and Griffiths, D.: Studies on the Inheritance of Dental Caries in the Harvard Strains of Caries-Susceptible and Caries-Resistant Rats, Arch Oral Biol 3: 247-257, 1961.[Medline]
[Order article via Infotrieve]
- Shaw, J.H.; Griffiths, D.; and Terborgh, A.: Attempts to Alter the Genetically Expected Caries Activity in Rats by Manipulation of the Oral Flora, Arch Oral Biol 7: 693-706, 1962.[Medline]
[Order article via Infotrieve]
- Larson, R.H.: Response of Harvard Caries-Susceptible and Caries-Resistant Rats to a Severe Cariogenic Challenge, J Dent Res 44:1402-1406, 1965.[Free Full Text]
- Chai, C.K.; Hunt, H.R.; Hoppert, C.A.; and RosEN, S.: Hereditary Basis of Caries Resistance in Rats, J Dent Res 47:127-138, 1968.[Abstract/Free Full Text]
- Cox, G.J.: Report of a Conference to Develop Uniform Standards and Procedures in Clinical Studies of Dental Caries, Am Dent Assn, Chicago, Illinois, 1955, p 50.
- Guggenheim, B.; Konig, K.G.; and Mühle-Mann, H.R.: Modifications of the Oral Bacterial Flora and their Influence on Dental Caries in the Rat I. The Effects of Inoculating Four Labelled Strains of Streptococci, Helv Odont Acta 9:121-129, 1965.
- Frostell, G.; Keyes, P.H.; and Larson, R.H.: The Effects of Various Sugars and Sugar Substitutes on Dental Caries in Hamsters and Rats, J Nutr 93:65-76, 1967.[Abstract/Free Full Text]
- Larson, R.H., and Zipkin, I.: Effect of Tetracycline on the Transmission of Dental Caries in Rats, J Dent Res 40:264-267, 1961.[Free Full Text]
- Keyes, P.H.: "Similarities and Differences in Dental Caries in Various Species," in R. S. Harris (ed.), The Art and Science of Dental Caries Research, New York: Academic Press, to be published.
Journal of Dental Research, Vol. 47, No. 5,
704-709 (1968)
DOI: 10.1177/00220345680470050701
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