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Figure 2. Synergistic effects of NOD1 and NOD2 agonists in combination with synthetic TLR agonists for induction of β-defensin 2 secretion in oral epithelial cells. Oral epithelial HSC-2 cells (a) and primary gingival epithelial cells (b) were stimulated with FK156 (100 µg/mL) or muramyldipeptide (MDP) (100 µg/mL) plus FSL-1 (1 nM), Poly I:C (10 µg/mL), lipid A (10 ng/mL), Poly U (10 µg/mL), or CpG DNA (10 nM) for 24 hrs in triplicate. Concentrations of β-defensin 2 in the culture supernatants were determined by ELISA, and expressed as means ± SD. *,#Marked values differed significantly from those obtained with medium alone or from respective cultures stimulated with the indicated ligands, respectively. The results presented are representative of 3 different experiments.
J DENT RES, Vol. 87, No. 7,
682-686 (2008)
DOI: 10.1177/154405910808700709
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