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Figure 2. SCPP gene clusters in the human (A), chicken (B), frog (C), fugu (D), and zebrafish (E) genomes. Location and transcriptional orientation of SPARCL1 (open box), P/Q-rich SCPP (closed box), acidic SCPP (shaded box), and ARHGAP6 (dashed-line box) genes are schematically illustrated. (A,C) AMEL is located within ARHGAP6 on human chromosome X and in the frog genome. (A) Two large SCPP gene clusters, enamel/milk/saliva and dentin/bone classes, are separated by 17 megabases (Mb). (D) Linkage of SPP1 and the other SCPP genes is unknown. (E) SPP1 and the other SCPP genes reside on different chromosomes. SCPP2-SCPP5 and SPARCL1-SCPP1 clusters are separated by 10 Mb by an intrachromosomal re-arrangement. These results are based on the following sequence assemblies: hg18 (human), galGal3 (chicken), xenTrop2 (frog), fr2 (fugu), and danRer5 (zebrafish).
J DENT RES, Vol. 87, No. 6,
520-531 (2008)
DOI: 10.1177/154405910808700608
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