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Figure 2. The anti-c-Fms antibody inhibited orthodontic tooth movement by inhibiting osteoclastogenesis, and had no effect on the side opposite the injection. Mice were injected daily with the anti-c-Fms antibody or PBS during orthodontic tooth movement. (A) Picture of tooth movement after mechanical loading for 12 days, with daily administration of PBS or anti-c-Fms antibody, and control. (B) The distance of tooth movement after mechanical loading for 12 days with daily administration of various doses of the anti-c-Fms antibody. n = 11 (0 µg), 9 (0.1 µg), 6 (1 µg), 5 (10 µg), and 5 (50 µg). (C) TRAP-stained horizontal section of tooth movement after mechanical loading for 12 days with daily administration of PBS or anti-c-Fms antibody and control. (D) The number of TRAP-positive multinuclear cells in control (1), or each mouse injected daily with PBS (2) or anti-c-Fms antibody (3) during orthodontic tooth movement. n = 4 each. (E) TRAP-stained transverse section of a tooth on the side opposite to the daily injection with PBS or anti-c-Fms antibody (10 µg) for 12 days. (F) The number of TRAP-positive multinuclear cells on the side opposite to the injection in mice injected daily with PBS (1) or anti-c-Fms antibody (2). n = 4 each. *p < 0.05 by the Mann-Whitney U-test. Scale bars: 1 mm in (B) and 100 µm in (C) and (E). Results are expressed as means ± SD.
J DENT RES, Vol. 87, No. 4,
396-400 (2008)
DOI: 10.1177/154405910808700405
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