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Figure 4. Inhibition of NF- B by aqueous ozone. In this study, pre-incubation with aqueous ozone (O3 medium) led, in TNF-stimulated cells, to an inhibition of IB proteolysis (Western blot analysis), NF-B DNA binding (electrophoretic mobility shift assay), and B-dependent transcription (luciferase assay), as well as to reduced expression of the target genes interleukin-8 and -1β (immunoassay). This indicates that aqueous ozone inhibited NF-B signaling at the level and/or upstream of IB. In the Fig., the classic NF-B dimer is depicted, consisting of the subunits p65 and p50. The activation pathway of NF-B is described in more detail in the INTRODUCTION.
J DENT RES, Vol. 86, No. 5,
451-456 (2007)
DOI: 10.1177/154405910708600512
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