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Figure 2. Synergistic effect of histamine for IL-8 production from gingival fibroblasts stimulated with TNF- , IL-1, and LPS. Gingival fibroblasts were incubated with 100 µmol/L of histamine (His) or medium (Med) for 2 hrs. The cells were then stimulated with TNF- (A), IL-1 (B), or LPS (C) at the indicated concentrations in the presence or absence of histamine at 100 µmol/L for 6 hrs for TNF- and IL-1 or 22 hrs for LPS. After the incubation, supernatants were collected, and the concentrations of IL-8 in the supernatants were determined by ELISA. The results are expressed as the mean ± SD for triplicate cultures. *p < 0.01 compared with Med His. #p < 0.05 and ##p < 0.01 compared with MedTNF-, MedIL-1, or MedLPS.
J DENT RES, Vol. 86, No. 11,
1083-1088 (2007)
DOI: 10.1177/154405910708601112
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