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Journal of Dental Research
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Table. Guidelines for BRONJ Prophylaxis
Management Strategy Clinical Scenario

Patients about to initiate oral bisphosphonate therapy No specific pre-treatment precautions. The importance of establishing and maintaining good oral health should be stressed.
Patients about to initiate IV bisphosphonate therapy Conduct clinical/radiographic dental examination to detect potential dental and periodontal infections.
Remove abscessed and non-restorable teeth and teeth with severe periodontal disease.
Remove teeth with poor long-term prognosis.
Functionally rehabilitate salvageable dentition.
Educate patients on oral hygiene and the signs and symptoms of BRONJ.
Asymptomatic patients receiving oral Dento-alveolar surgery is not contraindicated.
bisphosphonate therapy Consider interrupting BP treatment 3–4 weeks prior to surgery and re-starting after bone healing.
Asymptomatic patients receiving IV bisphosphonate therapy Avoid invasive dental procedures where possible.
Ensure good fit of dentures.
Aggressively manage dental infections non-surgically (root canal treatment, if possible).
Conduct regular dental assessments after initiating bisphosphonate therapy (frequency dependent upon risk).

J DENT RES, Vol. 86, No. 11, 1013-1021 (2007)
DOI: 10.1177/154405910708601101





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