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Figure 3. PGE₂ induced cementoblast-mediated cementclastogenesis via EP4 in a co-culture system of OCCM-30 and bone marrow cells. Number of nuclei, n; EP4 agonist, EP4A; EP4 antagonist, EP4R. PGE₂ (100 ng/mL) and the EP4 agonist (1 µM) induced TRAP-positive cells (A,B). Although PGE₂ induced multi-nucleated TRAP-positive cells, the EP4 agonist induced only mono-nucleated TRAP-positive cells (B). The EP4 antagonist (1 µM) completely suppressed the appearance of PGE₂-induced TRAP-positive cells. PGE₂ and the EP4 agonist stimulated pit formation on BD BioCoat^TM Osteologic^TM Multitest slides (C). Arrows indicate resorption pits. Results are expressed as the mean ± SD of 4 cultures. *p < 0.05 and **p < 0.01 vs. control.

J DENT RES, Vol. 86, No. 10, 974-979 (2007)
DOI: 10.1177/154405910708601011

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