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Figure 1. Integrin-mediated cell adhesion to extracellular matrices involves integrin binding and clustering, focal adhesion assembly, and cytoskeletal interactions. Focal adhesions are supramolecular assemblies containing structural and signaling components regulating cell functions. Immunofluorescence staining for osteoblasts (DNA white) adhering to fibronectin showing actin cytoskeleton stress fibers (red) terminating in focal adhesions as shown by vinculin localization (green). Focal adhesions indicated by green arrowhead. Bar = 10 µm.
J DENT RES, Vol. 84, No. 5,
407-413 (2005)
DOI: 10.1177/154405910508400502
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