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Figure 4. Schematic representation of PTHrP-induced osteoclast formation. PTHrP induces RANKL expression in PDL cells by a mechanism independent of the cAMP/PKA signaling pathway. PKC contributes to induction of RANKL mRNA induced by PTHrP in PDL cells as well as regulation of osteoclast precursor cell number. PGE2 induces RANKL expression in PDL cells via the cAMP/PKA signaling pathway.
J DENT RES, Vol. 84, No. 4,
329-334 (2005)
DOI: 10.1177/154405910508400407
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