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Figure 1. p21 (A–D) and Fgf4 (E–H) are expressed similarly in the molars of Runx2/Runx3 double-knockout and Runx2 knockout mice. (A,E,I) E13 wild-type, (B,F,J) E14 wild-type, (C,G,K) E14 Runx2 knockout mice, and (D,H) E14 Runx2/Runx3 double-knockout mice. (I–K) Runx3 expression is very weak in the wild-type tooth (I,J), but is intensely up-regulated in the dental mesenchyme of E14 Runx2 mutant upper molars (K). Arrows point to the down-regulation of p21 (C,D) and Fgf4 (G,H) in Runx2 knockout and Runx2/Runx3 double-knockout lower molars. Scale bar: 200 µm.
J DENT RES, Vol. 84, No. 2,
138-143 (2005)
DOI: 10.1177/154405910508400206
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