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Figure 3. Radiographic and photomicrographic images of tissue-engineered cranial suture and controls. (A) Representative radiographic image showing a lack of radiolucency in the tissue graft with two rhBMP2-loaded microporous collagen sponges without intervening autologous fibroblasts loaded in a gelatin scaffold. The adjacent coronal suture is labeled as ‘c’. (A') Corresponding microscopic image showing ossification of the surgically created calvarial defect without delivery of autologous fibroblasts or an intervening gelatin scaffold. (B) Representative radiographic image showing a lack of radiolucency in the tissue grafts with an intervening fibroblast-free, gelatin scaffold between two rhBMP2-loaded microporous collagen sponges. The adjacent coronal and sagittal sutures are labeled as ‘c’ and ‘s’, respectively. (B') Corresponding microscopic image showing ossification of the surgically created calvarial defect with fibroblast-free gelatin scaffold. (C) Representative radiographic image showing a band of radiolucency (between opposing white arrows) corresponding to the area of autologous fibroblasts loaded in a gelatin scaffold intervening between two rhBMP2-loaded microporous collagen sponges, indicating a fibrous tissue interface between mineralized bones. The adjacent coronal suture is labeled as ‘c’. (C') Corresponding microscopic image showing de novo formation of a fibrous tissue interface (f) between two mineralized bone segments (b) in the calvarial defect filled with fibroblast-seeded gelatin scaffold sandwiched between two rhBMP-loaded collagen sponges.
J DENT RES, Vol. 83, No. 10,
751-756 (2004)
DOI: 10.1177/154405910408301003
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