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Figure 2. Effect of pre-treatment with a β1-antagonist (atenolol), a β2-antagonist (ICI 118,551), or vehicle on norepinephrine (10 nM) inhibition of capsaicin-evoked release of iCGRP from bovine dental pulp. The β-adrenoceptor antagonists (both at 100 nM) or vehicle was pre-treated for 7 min prior to application of norepinephrine (10 nM) or vehicle for an additional 7 min. All groups were then stimulated with capsaicin (10 µM) for 7 min. ** p < 0.01 vs. vehicle and ICI 118,551 groups. Error bars are SEM. N = 6-8/group.
J DENT RES, Vol. 82, No. 4,
308-311 (2003)
DOI: 10.1177/154405910308200413
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