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Figure 3. The 1.1-kb Bmp4 gene region contains the control domains for Bmp4 expression in the epithelium-derived ameloblast. Sections of molars from newborn Bmp4lacZneo knock-in (A, labeled Bmp4LacZknock-in) mice, Bmp4LacZ2.4p (B), and Bmp4LacZ1.1p (C) mice were stained by the β-galactosidase antibody (green). A white arrow indicates the odontoblast layer in each panel, while a red one designates the ameloblast layer. Schematic presentation of the Bmp4 LacZ constructs is shown in the lower panels. Bmp4 promoter fragments –2372 to +258 (2.4 kb) and the -1140 to +212 (1.1 kb) are used to generate Bmp4LacZ2.4p and Bmp4LacZ1.1p mice. Abbreviations: Am, ameloblast; Od, odontoblast. The data shown are representative of three separate experiments in the same developmental stages.
J DENT RES, Vol. 81, No. 1,
6-10 (2002)
DOI: 10.1177/154405910208100103
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