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Salivary Procalcitonin and Periodontitis in Diabetes

¹ Washington, DC, Veterans Affairs Medical Center;
² NIDCR, CRC, NIH, Bldg. 10, Rm 1N-118, MSC 1191, 10 Center Drive, Bethesda, MD 20892, USA; and
³ George Washington University, Washington, DC, USA

View larger version (45K): [in this window] [in a new window]   Figure 1. Severe periodontitis is associated with increased procalcitonin. (A) Persons with severe periodontitis (, n = 9) had significantly higher levels of salivary-ProCT than did those with moderate periodontitis (, n=11, 241 ± 71 vs. 77 ± 516 pg/mL, p = 0.02), and also significantly higher levels than in healthy control individuals (, n = 8, 241 ± 71 vs. 118 ± 26 pg/mL, p = 0.05). The difference in serum-ProCT between persons with severe periodontitis (, n = 9) and those with moderate periodontitis (, n = 11) did not reach significance (107 ± 31 vs. 57 ± 6 pg/mL, p = 0.16), although the difference between those with severe periodontitis and healthy control individuals (, n = 38) was significant (102 ± 20 vs. 48 ± 3, p = 0.01). (B) Clinical radiographs of the periodontium (from left to right) of an individual with severe periodontitis, one with moderate periodontitis, and a healthy control individual.

View larger version (17K): [in this window] [in a new window]   Figure 2. Salivary-procalcitonin is correlated with periodontitis and diabetes status. (A) A positive correlation is shown between salivary-ProCT and bleeding-on-probing (BOP) (white triangle, n = 20, r = 0.45, p = 0.05). (B) Positive correlation between salivary-ProCT and HgbA1c (black squares, n = 20, r = 0.49, p = 0.03).

View larger version (9K): [in this window] [in a new window]   Figure 3. Levels of salivary-ProCT () were higher than matched serum-ProCT levels () for the periodontitis/diabetes group (n = 20, 152 ± 37 vs. 78 ± 17 pg/mL, p = 0.02). Salivary-ProCT in the control group (, n = 8) was also higher than the serum-ProCT of the healthy control individuals (, n = 38, 118 ± 146 vs. 48 ± 17 pg/mL, p = 0.01).

Journal of Dental Research, Vol. 87, No. 7, 630-634 (2008)
DOI: 10.1177/154405910808700707


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