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Journal of Dental Research
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Tooth Agenesis: from Molecular Genetics to Molecular Dentistry

E. Matalova1,3,*, J. Fleischmannova1,2, P.T. Sharpe4 and A.S. Tucker4

1 Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic;
2 Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;
3 Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; and
4 Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, United Kingdom


Figure 1
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  		Figure 1. Hypodontia, oligodontia, and anodontia defined according of the number of missing teeth and genes related to these abnormalities.

 

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  		Figure 2. Expression of molecules related to tooth agenesis during early tooth development, from bud to bell stages.

 

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  		Figure 3. Two major approaches to tooth regeneration. The developmental approach is based on repetition of embryonic tooth germ development. Stem cells are isolated, cultured (A1), and covered by embryonic epithelium (A2). After formation of the mesenchymal part of the tooth germ (A3), the epithelial part of the tooth germ is also replaced by stem cells (A4). Thus, the entire tooth germ originates from stem cells (A) and can further develop into a normal mineralized tooth (C). The other approach uses a supportive scaffold (B1) to seed dissolved tooth-derived cells (B2), which aggregate (B3) and form a new tooth of the given shape (C).

 

Journal of Dental Research, Vol. 87, No. 7, 617-623 (2008)
DOI: 10.1177/154405910808700715
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