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Journal of Dental Research
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Proteome of Human Minor Salivary Gland Secretion

W.L. Siqueira, E. Salih, D.L. Wan, E.J. Helmerhorst and F.G. Oppenheim*

Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, CABR, Suite W-201, Boston, MA 02118, USA


Figure 1
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  		Figure 1. Summary of the distribution of 56 proteins identified from labial minor salivary gland secretion with 3 different sample preparations.

 

Figure 2
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  		Figure 2. Base-peak chromatogram of one of the 12 fractions separated by cation exchange chromatography and analyzed by LC-ESI-MS/MS with a nano-flow reverse-phase HPLC column, with gradient elution ranging from 5 to 50% solvent B in 40 min (A). Cation exchange chromatogram of the tryptic peptides derived from proteins associated with labial minor salivary gland secretion (Inset). MS/MS spectrum and sequence analysis of a tryptic peptide. The sequence of R.TVQIAAVVDVIR.E led to the identification of "prolactin inducible protein" (P12273). Matching b- and y-ion series are indicated in the upper right (B).

 

Figure 3
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  		Figure 3. Classification of labial minor salivary gland secretion proteins according to their origin (A) and their biological functions (B). Information on origin and biological function was derived from protein annotations. Proteins with more than one origin and more than one biological function were counted multiple times.

 

Figure 4
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  		Figure 4. Relative proportions of major, minor, and novel salivary proteins in labial minor salivary gland secretion. *Histatin 1 was included based on the presence of the C-terminal 16-residue peptide found in all 3 sample preparations (A). MS/MS spectrum and sequence analysis of a tryptic peptide. The sequence of R.DPSQQELPR.L is indicative of the presence of "fatty acid synthase" (P49327). Matching band y-ion series are indicated in the upper right (B).

 

Journal of Dental Research, Vol. 87, No. 5, 445-450 (2008)
DOI: 10.1177/154405910808700508
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