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Genome-wide Scan Finds Suggestive Caries Loci

¹ Departments of Oral Biology,
² Pediatric Dentistry, and
³ Center for Craniofacial and Dental Genetics, 614 Salk Hall, University of Pittsburgh School of Dental Medicine, 3501 Terrace Street, Pittsburgh, PA 15261, USA;
⁴ Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh; and
⁵ Department of Psychiatry, School of Medicine, University of Pittsburgh

View larger version (27K): [in this window] [in a new window]   Figure 1. Multipoint parametric dominant and recessive linkage results summary of the two genome-wide scans for low caries susceptibility loci (DMFT categories 1 and 2, assigned as ‘affected’) and high caries susceptibility loci (DMFT categories 3 and 4, assigned as ‘affected’) in 46 families. Bars indicate the most significant LOD score results in each chromosome. In addition to chromosomes 5 and 13 that showed LOD scores above 2.0, several chromosomes (1, 2, 3, 4, 7, 8, 10, 11, 12, 14, 17, 18, and 19) showed LOD scores above 1.0. DMFT = Decayed, Missing due to caries, Filled Teeth; low DOM = multipoint parametric linkage analysis with a dominant model in low caries susceptibility; low REC = multipoint parametric linkage analysis with a recessive model in low caries susceptibility; high DOM = multipoint parametric linkage analysis with a dominant model in high caries susceptibility; high REC = multipoint parametric linkage analysis with a recessive model in high caries susceptibility.

View larger version (31K): [in this window] [in a new window]   Figure 2. Non-parametric linkage results summary (presented as negative logs of the p-values) of the 2 genome-wide scans for low caries susceptibility loci (DMFT categories 1 and 2, assigned as ‘affected’) and high caries susceptibility loci (DMFT categories 3 and 4, assigned as ‘affected’) in 46 families. Bars indicate the –log linear of the most significant p values in each chromosome. In addition to chromosome X (p = 0.00005), chromosomes 5 (p = 0.001), 6 (p = 0.009), 13 (p = 0.006), and 22 (p = 0.004) presented interesting results. DMFT = Decayed, Missing due to caries, Filled Teeth; single low = single-point linkage analysis in low caries susceptibility; multi low = multipoint linkage analysis in low caries susceptibility; single high = single-point linkage analysis in high caries susceptibility; multi high = multipoint linkage analysis in high caries susceptibility.

Journal of Dental Research, Vol. 87, No. 5, 435-439 (2008)
DOI: 10.1177/154405910808700506


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