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Effects of Fluoride Dentifrices on Enamel Lesion Formation

¹ Division of Oral Health, Department of Health Science, Kanagawa Dental College, Japan; and
² Department of Preventive and Restorative Dental Sciences, University of California San Francisco, Box 0758, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA

View larger version (15K): [in this window] [in a new window]   Figure 1. Free fluoride concentrations over time of test groups A (AmF dentifrice with nominally 1250 ppm F), B (NaMFP dentifrice with nominally 1000 ppm F), C (NaF dentifrice with nominally 1100 ppm F), D (NaF dentifrice with nominally 250 ppm F), E (placebo dentifrice containing no added fluoride), F (NaF 900 ppm F aqueous solution), and G (NaF 30 ppm F aqueous solution). Each line joins datapoints for each test group for adjacent timepoints. There were 3 replicates at each timepoint. Y-axis error bars to all mean values show standard error of mean. In some cases, the symbols are larger than the error bar.

View larger version (15K): [in this window] [in a new window]   Figure 2. Enamel lesion profile (volume % mineral vs. depth from the outer surface) for enamel window data for test groups A (AmF dentifrice with nominally 1250 ppm F), B (NaMFP dentifrice with nominally 1000 ppm F), C (NaF dentifrice with nominally 1100 ppm F), D (NaF dentifrice with nominally 250 ppm F), E (placebo dentifrice containing no added fluoride), F (NaF 900 ppm F aqueous solution), and G (NaF 30 ppm F aqueous solution). Each point on each line is the mean volume % mineral for the group at that depth. Each test group consisted of 10 enamel crowns, and y-axis error bars to all mean values show standard error of mean. In some cases, the symbols are larger than the error bars.

View larger version (7K): [in this window] [in a new window]   Figure 3. Log F concentrations of NaF dentifrices and aqueous solutions vs. relative mineral loss (Z, volume % mineral x µm). The straight line is the linear regression line. A plot of logF for the NaF dentifrices, the placebo dentifrice (approximately 1 ppm F), and the fluoride in solutions showed a good linear relationship with F concentration (Pearson r = – 0.962 for the linear regression line). Each test group consisted of 10 enamel crowns, and y-axis error bars to all mean values show standard error of mean.

Journal of Dental Research, Vol. 87, No. 3, 224-227 (2008)
DOI: 10.1177/154405910808700303


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