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Journal of Dental Research
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Cathepsin C Gene Variants in Aggressive Periodontitis

B. Noack1,*, H. Görgens2, U. Hempel3, J. Fanghänel4, Th. Hoffmann1, A. Ziegler5 and H.K. Schackert2

1 Department of Conservative Dentistry,
2 Department of Surgical Research, and
3 Institute of Physiological Chemistry, Dresden University of Technology, Medical Faculty, Fetscherstrasse 74, 01307, Dresden, Germany;
4 Department of Periodontology, Ernst Moritz Arndt University, Greifswald, Germany; and
5 Institute of Medical Biometry and Statistics, University at Lübeck, Germany


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  		Figure 1. CTSC enzyme activity in polymorphonuclear leukocytes. The bars represent the means of triplicate determinations ± standard deviation. CTSC activity is expressed as change of optical density per min in 105 cells ({Delta}OD/min*105 cells) according to Pham et al.(2004). The difference between homozygous wild-type individuals and heterozygous carriers of 1 rare allele is statistically significant (p = 0.018, u-test)

 

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  		Figure 2. Example of mRNA expression analysis. (A,B) Sequences showing equal abundance of the c.1173 T>G (p.Thr391Thr) variant and wild-type allele in cDNA templates (A) and genomic DNA templates (B). (C,D) Sequences showing equal abundance of the c.1357 A>G (p.Ile453Val) variant and wild-type allele in cDNA templates (C) and genomic DNA templates (D). These variants in exon 7 were found in tight linkage disequilibrium with 3 promoter variants (c.-260del, c.-259del, and c.-232T>C).

 

Journal of Dental Research, Vol. 87, No. 10, 958-963 (2008)
DOI: 10.1177/154405910808701017
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