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Journal of Dental Research
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Host Defense Peptides in the Oral Cavity and the Lung: Similarities and Differences

G. Diamond1,*, N. Beckloff1,+ and L.K. Ryan2

1 Department of Oral Biology, UMDNJ-New Jersey Dental School, 185 South Orange Ave., Newark 07103, NJ 07101, USA; and
2 Public Health Research Institute and Division of Pulmonary and Critical Care Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07101, USA


Figure 1
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  		Figure 1. ClustalW alignment of human {alpha}- and β-defensins. The mature peptide sequences of {alpha}- and β-defensins are aligned with the number of amino acids listed on the right. Amino acids are annotated based on the ClustalW scheme for physical characteristics: uppercase for small and hydrophobic, italic for acidic, boldface for basic, and underlined for hydroxyl, amide, and basic. Highly conserved residues in each sequence are denoted by an asterisk.

 

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  		Figure 2. Pathways stimulated by microbes and their associated molecular patterns in oral (A) and airway (B) epithelial cells leading to β-defensin expression. These models are based solely on published studies demonstrating the role of the respective receptors, adapter molecules, and transcription factors. In some cases, e.g., stimulation of hBD-2 by P. intermedia, specific stimulatory molecule, receptor, pathway, and/or transcription factors have not been identified, and are shown as a question mark.

 

Journal of Dental Research, Vol. 87, No. 10, 915-927 (2008)
DOI: 10.1177/154405910808701011
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