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Sphingomyelin Degradation is a Key Factor in Dentin and Bone Mineralization: Lessons from the fro/fro Mouse

¹ Laboratoire "Réparation et Remodelage des Tissus Orofaciaux", EA 2496, Faculté de Chirurgie Dentaire, Université Paris 5, 1, rue Maurice Arnoux, Montrouge 92120, France;
² Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France; and
³ Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY, USA

View larger version (111K): [in this window] [in a new window]   Figure 1. Longitudinal sections of mandibles of newborn mice. (a) +/fro and (b) fro/fro. The incisor is shorter in the fro/fro mouse. The profile of the molar (m) is affected by the mutation. (c,d) Transverse sections of the mandibles of +/fro and fro/fro newborn mice. von Kossa staining reveals that the alveolar bone of the fro/fro mouse is hypomineralized, with fewer trabeculae (arrows). Because the incisor is shorter in the fro/fro mouse, no incisor is seen in (d), when the section plane is at the level of the first molar (m). (a–d) Bars = 100 µm. (e) A transverse section of a young +/fro adult, with a large pulp (asterisk). The alveolar bone (ab) is dense. In contrast, (f) shows, in a transverse section of an age-matched adult fro/fro mouse, that the pulp chamber in the molar is filled with dentin-like tissue (asterisk). Alveolar bone (ab) looks less compact compared with the +/fro. (e,f) Bars = 150 µm.

View larger version (121K): [in this window] [in a new window]   Figure 2. Molars of adult fro/fro mice. (a) Higher magnification of the apical part of the molar of an adult fro/fro mouse. The formation of a thick layer of cellular cementum and the filling of the root pulp (p) by dentin-like tissue, in continuity with the dentin (d), constitute the dental phenotype of the mutated mouse. The periodontal ligament (pdl) and alveolar bone (ab) look normal. Bar = 150 µm. The transverse section of an adult fro/fro mouse observed by scanning electron microscopy (b) displays similarities to the human type II dentin dysplasia. e, enamel; d, dentin; p, pulp; ab, alveolar bone. Bar: 1 mm.

Journal of Dental Research, Vol. 87, No. 1, 9-13 (2008)
DOI: 10.1177/154405910808700103


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