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Journal of Dental Research
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Apoptosis in Gingival Overgrowth Tissues

A. Kantarci1, P. Augustin2, E. Firatli3, M.C. Sheff4, H. Hasturk1, D.T. Graves1 and P.C. Trackman1,5,*

1 Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 700 Albany Street W-210, Boston, MA 02118, USA;
2 Department of Periodontology, Dental Clinic, St. Ann’s Teaching Hospital, Pekarska 53, 656 91 Brno, Czech Republic;
3 Department of Periodontology, Istanbul University, Faculty of Dentistry, Istanbul, Turkey;
4 Franciscan Hospital for Children, Boston, MA, USA; and
5 Department of Biochemistry, Boston University, School of Medicine, Boston, MA, USA


Figure 1
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  		Figure 1. Apoptotic index (% TUNEL-positive fibroblasts) (A) and proliferative index (% PCNA-positive fibroblasts) (B) in gingival overgrowth and control tissue samples. Data are expressed as means ± SD. In (A), the numbers of independent samples (n) per group are: no overgrowth control, 6; phenytoin overgrowth, 8; cyclosporin A overgrowth, 7; nifedipine overgrowth, 7; and gingival fibromatosis, 12. *p < 0.05 compared with control, cyclosporin A, and nifedipine; **p < 0.05 compared with control; #p < 0.05 compared with non-inflamed. In (B), (n) per group is: control, 6; phenytoin, 6; cyclosporin A, 6; nifedipine, 6; gingival and fibromatosis, 12. *p < 0.05 compared with control.

 

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  		Figure 2. Caspase 3 expression in gingival tissues. Quantitative histomorphometric analyses of caspase 3 immunostaining in all forms of gingival overgrowth in inflamed and non-inflamed tissue areas (0.09 mm2). (n) per group is: control, 6; phenytoin, 8; cyclosporin A, 7; nifedipine, 7; and gingival fibromatosis, 12. *p < 0.05 compared with control and cyclosporin A; **p < 0.05 compared with control.

 

Figure 3
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  		Figure 3. FOXO1 expression in gingival overgrowth and no overgrowth control tissues. (A) Representative sections for the immunohistochemical staining of FOXO1 expression in phenytoin and control tissues. Black arrows designate fibroblasts stained positive for FOXO1. Each bar represents 200 µm at a magnification of 200x. (B) Histomorphometric and quantitative analyses of FOXO1 immunostaining in all forms of gingival overgrowth in inflamed and non-inflamed tissue areas (0.09 mm2). (n) for control, 6; for phenytoin, 6; for cyclosporin A, 6; for nifedipine, 6; and for gingival fibromatosis, 8. *p < 0.05 compared with control; #p < 0.05 compared with non-inflamed.

 

Journal of Dental Research, Vol. 86, No. 9, 888-892 (2007)
DOI: 10.1177/154405910708600916
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