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Journal of Dental Research
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p38 Pathway Kinases as Anti-inflammatory Drug Targets

J.F. Schindler, J.B. Monahan and W.G. Smith*

Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA


Figure 1
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  		Figure 1. p38 MAPK signaling pathway.

 

Figure 3
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  		Figure 3. p38 MAPK regulation of inflammation.

 

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  		Figure 2. p38 MAPK and MK2 inhibitors.

 

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  		Figure 4. p38/MK2 regulation of inflammatory gene expression.

 

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  		Figure 5. Crystal structure of the ATP binding pocket of: (a) p38a/SC80036 complex, (b) p38a/VX-745 complex, (c) p38a/BIRB-796 complex, and (d) MK2/compound 23 complex.

 

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  		Figure 6. Ex vivo correlation of inhibition of p38 MAPK activity with that of inflammatory cytokine release by SC80036 in (A) U937 cells or (B) human whole blood (Burnette et al., submitted to J Pharmacol Exp Ther).

 

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  		Figure 7. Effect of SC79659 on LPS-induced inflammatory cytokine production in rodents (Burnette et al., submitted to J Pharmacol Exp Ther).

 

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  		Figure 8. In vivo inhibition of TNF-{alpha} release by SC80036 in a human experimental endotoxemia clinical trial and correlation with inhibition of p38 MAPK activity (Burnette et al., submitted to J Pharmacol Exp Ther).

 

Journal of Dental Research, Vol. 86, No. 9, 800-811 (2007)
DOI: 10.1177/154405910708600902
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