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Journal of Dental Research
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Dioxin Alters Gene Expression in Mouse Embryonic Tooth Explants

C. Sahlberg1,*, E. Peltonen1, P.-L. Lukinmaa2,3 and S. Alaluusua1,4

1 Department of Pediatric and Preventive Dentistry, Institute of Dentistry, Biomedicum Helsinki, PL 63 (Haartmaninkatu 8), FIN-00014 UNIVERSITY OF HELSINKI, Helsinki, Finland;
2 Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland;
3 Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland; and
4 Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland


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  		Figure 1. Array gene sets induced or repressed at least two-fold in E14 molars exposed to 1 µM TCDD for 24 hrs in tissue culture. The scale of the X-axis is logarithmic.

 

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  		Figure 2. Mean fold changes in qPCR assays. Relative expression ratios showing relative changes in unexposed compared with TCDD-exposed mouse molars after normalization to actin-β (= 1). Up-regulation is seen for CYP1b1 (3.42 ± 1.7), Fst (3.35 ± 2.2), and Runx2 (1.96 ± 1.0), and p21 (0.70 ± 0.1) and TGFβ1 (0.58 ± 0.2) are down-regulated. Each column consists of 9 datapoints for each gene. Results are mean ± SD of triplicate analyses.

 

Journal of Dental Research, Vol. 86, No. 7, 600-605 (2007)
DOI: 10.1177/154405910708600704
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