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Journal of Dental Research
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Mouse Molar Dentin Size/Shape is Dependent on Growth Hormone Status

J.R. Smid1,*, J.E. Rowland2, W.G. Young1, K.T. Coschigano3, J.J. Kopchick3,4 and M.J. Waters5

1 Oral Biology and Pathology, School of Dentistry, and
5 Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia;
2 AgResearch Limited, Hamilton, New Zealand; and
3 Department of Biomedical Sciences and
4 Edison Biotechnology Institute, Ohio University, Athens, OH, USA


Figure 1
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  		Figure 1. Outline of a longitudinal section of a mouse mandibular first molar tooth:

  • crown dentin (a), superior to the axis of cemento-enamel junctions (J, J') and enclosed by the dentino-enamel junction (JEJ') (enamel removed by decalcification) and the dentin-pulp interface (PP').
  • crown pulp (b), inferior to crown dentin (a) and superior to the axis of the cemento-enamel junctions (JJ');
  • apical cellular cementum (c), outline;
  • dorsal root dentin (d), inferior to the cemento-enamel junction axis (JP) and enclosed by the dentino-cemental junction (JA) and the dentin-pulp interface (PA);
  • mesial root dentin (e), inferior to the cemento-enamel junction axis (P'J') and enclosed by the dentino-cemental junction (J'A') and the dentin-pulp interface (P'A'); and
  • root dentin of the furcation (f), outline.

Scale bar = 0.50 mm.

 

Figure 2
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  		Figure 2. Measured dimensions of decalcified longitudinal sections of mouse mandibular first molar teeth of bovine GH transgenic B6/SJL mice, with either the giant mutant (GH-Excess) or the wild-type (Wt) genotype (n = 10). (A) Dentino-enamel junction length and mesio-distal crown width. (B) Mesial and distal dentin root lengths and their corresponding (Mesial Width, Distal Width) thicknesses. (C) Cross-sectional areas of coronal (Crown), (Mesial Root), (Distal Root) dentin and their summation (Sum Total) for individual mouse teeth. All mice were 45 days of age. All dimensions are presented as mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001. One-way ANOVA.

 

Figure 3
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  		Figure 3. Measured dimensions of decalcified longitudinal sections of mouse mandibular first molar teeth of bovine GH-Antagonist transgenic C57BL/6J mice, with either the dwarf mutant (GH-Antagonist) or the wild-type (Wt) genotype (n = 10). (A) Dentino-enamel junction length and mesio-distal crown width. (B) Mesial and distal dentin root lengths and their corresponding (Mesial Width, Distal Width) thicknesses. (C) Cross-sectional areas of coronal (Crown), (Mesial Root), (Distal Root) dentin and their summation (Sum Total) for individual mouse teeth. All mice were 45 days of age. All dimensions are presented as means ± SEM. ***P < 0.001; One-way ANOVA.

 

Figure 4
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  		Figure 4. Measured dimensions of decalcified longitudinal sections of mouse mandibular first molar teeth of GH-receptor-knockout 129OLA/BalbC mice with genotype groups: wild-type (Wt), heterozygous (Het) mice, and dwarf homozygous (GH-Receptor-KO). (A) Dentino-enamel junction length and mesio-distal crown width. (B) Mesial and distal dentin root lengths and their corresponding (Mesial Width, Distal Width) thicknesses. (C) Cross-sectional areas of coronal (Crown), (Mesial Root), (Distal Root) dentin and their summation (Sum Total) for individual mouse teeth. All mice were 45 days of age. All data: Wt, n = 8; Het, n = 9; GH-Receptor-KO, n = 7, except (B) Mesial Length (Wt, n = 8; Het, n = 8; GH-Receptor-KO, n = 7), (C) Mesial Root (Wt, n = 8; Het, n = 8; GH-Receptor-KO, n = 7), and (C) Sum Total (Wt, n = 7; Het, n = 8; GH-Receptor-KO, n = 6). All dimensions are presented as means ± SEM. ***P < 0.001; One-way ANOVA.

 

Journal of Dental Research, Vol. 86, No. 5, 463-468 (2007)
DOI: 10.1177/154405910708600514
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