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Submandibular Glands Contribute to Increases in Plasma BDNF Levels

¹ Department of Maxillofacial Diagnostic Science, Division of Pathology,
² Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, and
³ Department of Oral Medicine, Division of Operative Dentistry and Endodontics, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan

View larger version (18K): [in this window] [in a new window]   Figure 1. Stress levels following immobilization stress. For stressed rats, ACTH levels were 2657.5 ± 668.64 pg/mL at 30 min, 2404.54 ± 679.74 pg/mL at 60 min, and 1306.66 ± 453.46 pg/mL at 180 min (N = 4; error bars = SD). Non-stressed rats had ACTH levels of 775.833 ± 121.12 pg/mL. There were significant differences in the ACTH levels of non-stressed rats and rats that experienced 30, 60, or 180 min of acute immobilization stress (p < 0.05).

View larger version (15K): [in this window] [in a new window]   Figure 2. BDNF protein levels following immobilization stress. Plasma BDNF level was 6.15 ± 1.64 pg/mL for non-stressed rats (N = 4; error bars = SD). For stressed rats, plasma BDNF levels were 4.31 ± 0.33 pg/mL at 30 min, 65.5 ± 19.7 pg/mL at 60 min, and 15.64 ± 3.32 pg/mL at 180 min (N = 4; error bars = SD). Significant differences were found in plasma BDNF levels between non-stressed rats and those that experienced 60 min or 180 min of acute immobilization stress (p < 0.05). Significant differences were noted between rats that experienced 30 min and those that experienced 60 or 180 min of acute immobilization stress (p < 0.05), and also between rats that experienced 60 min and 180 min of stress. Acute immobilization stress for 60 min significantly increased the level of plasma BDNF.

View larger version (18K): [in this window] [in a new window]   Figure 3. BDNF protein levels in sialoadenectomized rats. (A) Plasma BDNF levels in non-stressed rats. Plasma BDNF levels were 6.15 ± 1.64 pg/mL in normal rats and 8.01 ± 5.07 pg/mL in sialoadenectomized rats (N = 4; error bars = SD). (B) Plasma BDNF levels in stressed rats. Plasma BDNF levels were 65.5 ± 19.7 pg/mL in normal rats and 27.9 ± 14.8 pg/mL in sialoadenectomized rats (N = 4; error bars = SD). There were significant differences in plasma BDNF levels between non-sialoadenectomized rats and sialoadenectomized rats (p < 0.05).

Journal of Dental Research, Vol. 86, No. 3, 260-264 (2007)
DOI: 10.1177/154405910708600312


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