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Journal of Dental Research
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Tissue-engineered Oral Mucosa: a Review of the Scientific Literature

K. Moharamzadeh1,*, I.M. Brook1, R. Van Noort1, A.M. Scutt2 and M.H. Thornhill1

1 School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, United Kingdom; and
2 Department of Engineering Materials, University of Sheffield, Broad Lane, Sheffield, S3 7HQ, United Kingdom


Figure 1
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  		Figure 1. Monolayer culture of human oral keratinocytes on a collagen-coated flask.

 

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  		Figure 2. Histological sections of (A) normal oral mucosa biopsy, (B) tissue-engineered skin, and (C) tissue-engineered oral mucosa.

 

Figure 3
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  		Figure 3. De-epidermalized dermis (DED). (A) Macroscopic view. (B) Histological section of oral mucosa reconstructed on DED.

 

Figure 4
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  		Figure 4. The co-culture system developed by Moriyama et al. for fabricating composite cultured oral mucosa. Culture was performed at the air-liquid interface. (A) Keratinocytes; (B) fibroblasts; (C) collagen sponge and collagen gel; (D) millipore filter; and (E) steel mesh.

 

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  		Figure 5. Different biological endpoints for the in vitro assessment of the response of engineered oral mucosa to an applied stimulus.

 

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  		Figure 6. Histological picture of Candida albicans colonization and invasion of tissue-engineered oral epithelium.

 

Figure 7
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  		Figure 7. Lymphocytes incorporated into tissue-engineered oral epithelium.

 

Journal of Dental Research, Vol. 86, No. 2, 115-124 (2007)
DOI: 10.1177/154405910708600203
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