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Journal of Dental Research
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The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus

C.C.R. Ragin1,2,5,*, F. Modugno2,5 and S.M. Gollin1,3,4,5

1 Departments of Human Genetics and
2 Epidemiology, the University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Room A300,
3 Otolaryngology, and Pathology, the University of Pittsburgh School of Medicine,
4 the Head and Neck SPORE at the University of Pittsburgh, and the
5 University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA


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  		Figure. The multifactorial model of HNSCC carcinogenesis. Tobacco- and alcohol-related head and neck tumors are predominantly negative for HPV. However, there may be a subset of HPV-positive tumors in which the virus may (in E6/E7 expressors) or may not (in E6/E7 non-expressors) play a role in carcinogenesis. In the absence of tobacco and alcohol use, head and neck tumors may or may not be positive for HPV. The virus may function as a carcinogen in those tumors that express E6/E7. Risk factors other than HPV may account for the development of HPV-negative as well as HPV-positive, E6/E7 non-expressing tumors.

 

Journal of Dental Research, Vol. 86, No. 2, 104-114 (2007)
DOI: 10.1177/154405910708600202
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