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Journal of Dental Research
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Craniofacial Morphology in Myostatin-deficient Mice

L. Vecchione1,5,*, C. Byron2, G.M. Cooper1, T. Barbano3, M.W. Hamrick4, J.J. Sciote5 and M.P. Mooney1,3,5,6

1 Department of Plastic Surgery,
3 Department of Anthropology,
5 Department of Orthodontics & Dentofacial Orthopedics, and
6 Department of Oral Biology, University of Pittsburgh, PA, USA;
2 Department of Biology, Mercer University, Macon, GA, USA; and
4 Department of Cellular Biology & Anatomy, Medical College of Georgia, Augusta, USA


Figure 1
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  		Figure 1. Mean (± SE) body weight (top) and masseter muscle weight (bottom) by group and the results of statistical analysis. Note the significantly greater weights in the myostatin-deficient mice (N = 7) compared with the wild-type mice (N = 9).

 

Figure 2
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  		Figure 2. Dorso-ventral (top row) and lateral (middle and bottom rows) radiographs from wild-type control (left column) (N = 9) and myostatin-deficient (right column) (N = 7) mice. Note the shortened cranial vault (CV) and maxilla (Mx) in the myostatin-deficient skull (B,D) compared with the wild-type skull (A,C), producing brachycephaly in the myostatin-deficient skull. Also note the dramatically altered ramus and coronoid process (CP), and the elongated and rounded body in the myostatin-deficient mandible (F) compared with the wild-type mandible (E), producing a "rocker-type" mandibular morphology.

 

Figure 3
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  		Figure 3. Mean (± SE) maxillary length (top) and cranial vault length (bottom) by group and the results of statistical analysis. Note the significantly shorter maxillae and cranial vaults in the myostatin-deficient mice (N = 7) compared with the wild-type mice (N = 9).

 

Figure 4
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  		Figure 4. Mean (± SE) mandibular length (top) and mandibular shape index (bottom) by group and the results of statistical analysis. Note the significantly longer mandibles and smaller indices in the myostatin-deficient mice (N = 7) compared with the wild-type mice (N = 9).

 

Journal of Dental Research, Vol. 86, No. 11, 1068-1072 (2007)
DOI: 10.1177/154405910708601109
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