Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ford, P.J.
Right arrow Articles by Seymour, G.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ford, P.J.
Right arrow Articles by Seymour, G.J.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Anti-P. gingivalis Response Correlates with Atherosclerosis

P.J. Ford1,*, E. Gemmell1, P. Timms2, A. Chan1, F.M. Preston1 and G.J. Seymour1

1 Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane 4072, Australia; and
2 Infectious Diseases Program, Science Research Centre, School of Life Sciences, Queensland University of Technology, Brisbane 4001, Australia


Figure 1
View larger version (95K):
[in this window]
[in a new window]

  		Figure 1. Mice immunized with P. gingivalis (A) and C. pneumoniae (B) demonstrated marked atherosclerotic lesions in the proximal aorta, as observed with Oil red O staining, compared with control mice (C) after 26 wks of immunizations. Dark-staining areas in the wall of the aorta are lipid-filled atherosclerotic lesions. Cross-sections of the proximal aorta show atherosclerotic lesions dominated by Mac-3 staining cells (D). Endothelial cells and some lesional cells stain positively for HSP60 (E). Original magnification 40X. Scale shown represents 100 µm.

 

Figure 2
View larger version (16K):
[in this window]
[in a new window]

  		Figure 2. Mean cross-sectional atherosclerotic lesion area of the proximal aorta of mice immunized with P. gingivalis (Pg), C. pneumoniae (Cp), or vehicle (v). Results are mean ± SEM of 6 mice per group. *P < 0.001; **P < 0.036; ***P < 0.043.

 

Figure 3
View larger version (17K):
[in this window]
[in a new window]

  		Figure 3. Serum antibody levels of immunized mice. (A) Anti-P. gingivalis; (B) anti-C. pneumoniae; and (C) anti-GroEL serum IgG antibody levels of mice immunized with P. gingivalis (Pg), C. pneumoniae (Cp), or vehicle (v). Results are mean ± SEM of 6 mice per group.

 

Journal of Dental Research, Vol. 86, No. 1, 35-40 (2007)
DOI: 10.1177/154405910708600105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?