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Journal of Dental Research
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Clodronate Inhibits PGE2 Production in Compressed Periodontal Ligament Cells

L. Liu1,4, K. Igarashi2,*, H. Kanzaki1, M. Chiba2, H. Shinoda3 and H. Mitani1

1 Divisions of Orthodontics and Dentofacial Orthopedics,
2 Oral Dysfunction Science, and
3 Dental Pharmacology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan


Figure 1
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  		Figure 1. Effects of clodronate on prostaglandin E2 (PGE2) (A), interleukin 1β (IL-1β) (B), and nitric oxide (NO) (C) production in periodontal ligament cells induced by compressive mechanical stress. Each column and bar represent the mean ± SEM (n = 3). *Significant increase vs. control (P < 0.05). **Significant increase vs. control (P < 0.01). {dagger}P < 0.05 compared with load. {dagger}{dagger}P < 0.01 compared with load. CLO: clodronate (5, 25, 125 µM).

 

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  		Figure 2. Effect of clodronate on gene expression for cyclo-oxygenase-2 (COX-2) and receptor activator nuclear factor {kappa}B ligand (RANKL) in compressed periodontal ligament cells. (A) RT-PCR for COX-2, RANKL, and β-actin. CLO: 125 µM. (B) Relative expression of RANKL mRNA and COX-2 mRNA determined by densitometric analysis. Values were corrected for β-actin mRNA expression. Representative results of 1 of 3 independent experiments are shown. CLO: clodronate (5, 25, 125 µM).

 

Journal of Dental Research, Vol. 85, No. 8, 757-760 (2006)
DOI: 10.1177/154405910608500813
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