Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Li, C.H.
Right arrow Articles by Amar, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, C.H.
Right arrow Articles by Amar, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Role of Secreted Frizzled-related Protein 1 (SFRP1) in Wound Healing

C.H. Li and S. Amar*

Department of Periodontology & Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, W-201E, Boston, MA 02118, USA


Figure 1
Figure 1
View larger version (58K):
[in this window]
[in a new window]

  		Figure 1. Progress in palatal and dermal wound healing. (A) Epithelial gap, (B) connective tissue gap, (C) area of new connective tissue formation, and (D) percentage of new connective tissue formation relative to the area of original excisional defect were measured on H&E-stained wound sections. (E) Wound histology on day 10. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test.

 

Figure 2
View larger version (8K):
[in this window]
[in a new window]

  		Figure 2. Inflammatory cell infiltrate in palatal and dermal wounds. (A) PMN and (B) mononuclear cell infiltrates were measured by identification of their characteristic appearance on H&E-stained wound sections. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test.

 

Figure 3
View larger version (61K):
[in this window]
[in a new window]

  		Figure 3. Apoptosis and SFRP1 expression in palatal and dermal wounds. (A) Apoptotic inflammatory cells and (B) fibroblasts were analyzed and quantified, then presented as percentages of apoptotic cells relative to the total cell counts in the same field of analysis by TUNEL assay. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test. (C) Wound histology on day 10. Arrows show apoptotic fibroblasts. (D) Fibroblasts were analyzed by immunohistochemical staining and quantification of SFRP1-immunopositive cells. Each value represents the mean ± SEM; n = 5). (E) Wound histology on day 14. Arrows show SFRP1-positive fibroblasts.

 

Figure 4
View larger version (18K):
[in this window]
[in a new window]

  		Figure 4. Blocking SFRP1 in palatal wounds. (A) Epithelial and connective tissue gaps, (B) area of new connective tissue formation, (C) percentage of new connective tissue formation relative to the area of original excisional defect, (D) the number of PMNs, and (E) mononuclear inflammatory cells, (F) the percentage of apoptotic inflammatory cells and (G) fibroblasts, and (H) SFRP1 expression in uninjected (palatal group on day 10) and anti-SFRP1 antibody-injected groups. Each value represents the mean ± SEM (n = 5). *i.e., p < 0.05 by Student’s t test.

 

Journal of Dental Research, Vol. 85, No. 4, 374-378 (2006)
DOI: 10.1177/154405910608500418
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?