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Journal of Dental Research
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Role of Secreted Frizzled-related Protein 1 (SFRP1) in Wound Healing

C.H. Li and S. Amar*

Department of Periodontology & Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, W-201E, Boston, MA 02118, USA


Figure 1
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  		Figure 1. Progress in palatal and dermal wound healing. (A) Epithelial gap, (B) connective tissue gap, (C) area of new connective tissue formation, and (D) percentage of new connective tissue formation relative to the area of original excisional defect were measured on H&E-stained wound sections. (E) Wound histology on day 10. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test.

 

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  		Figure 2. Inflammatory cell infiltrate in palatal and dermal wounds. (A) PMN and (B) mononuclear cell infiltrates were measured by identification of their characteristic appearance on H&E-stained wound sections. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test.

 

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  		Figure 3. Apoptosis and SFRP1 expression in palatal and dermal wounds. (A) Apoptotic inflammatory cells and (B) fibroblasts were analyzed and quantified, then presented as percentages of apoptotic cells relative to the total cell counts in the same field of analysis by TUNEL assay. Each value represents the mean ± SD (n = 5). *i.e., p < 0.05 by Student’s t test. (C) Wound histology on day 10. Arrows show apoptotic fibroblasts. (D) Fibroblasts were analyzed by immunohistochemical staining and quantification of SFRP1-immunopositive cells. Each value represents the mean ± SEM; n = 5). (E) Wound histology on day 14. Arrows show SFRP1-positive fibroblasts.

 

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  		Figure 4. Blocking SFRP1 in palatal wounds. (A) Epithelial and connective tissue gaps, (B) area of new connective tissue formation, (C) percentage of new connective tissue formation relative to the area of original excisional defect, (D) the number of PMNs, and (E) mononuclear inflammatory cells, (F) the percentage of apoptotic inflammatory cells and (G) fibroblasts, and (H) SFRP1 expression in uninjected (palatal group on day 10) and anti-SFRP1 antibody-injected groups. Each value represents the mean ± SEM (n = 5). *i.e., p < 0.05 by Student’s t test.

 

Journal of Dental Research, Vol. 85, No. 4, 374-378 (2006)
DOI: 10.1177/154405910608500418
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