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Journal of Dental Research
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Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens

C. Bodet, F. Chandad and D. Grenier*

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec City, Québec, Canada G1K 7P4


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  		Figure 1. Effect of treating macrophages with fraction 1 (non-dialyzable material of cranberry juice), fraction 2 (cranberry juice), and epigallocatechin gallate (EGCG) on the secretion of IL-6 (A), TNF-{alpha} (B), and IL-1β (C) induced by LPS (1 µg/mL) of A. actinomycetemcomitans ATCC 29522 for 24 hrs. Macrophages were treated with cranberry fractions, or EGCG, for 2 hrs prior to lipopolysaccharides (LPS) stimulation. Cytokine secretion was assessed by ELISA. The data are the means ± standard deviations of triplicate assays for three independent experiments. *P value of < 0.05 compared with untreated control.

 

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  		Figure 2. Effect of treating macrophages with fraction 1 (non-dialyzable material of cranberry juice), fraction 2 (cranberry juice), and epigallocatechin gallate (EGCG) on the secretion of IL-8 (A) and RANTES (B) induced by LPS (1 µg/mL) of A. actinomycetemcomitans ATCC 29522 for 24 hrs. Macrophages were treated with cranberry fractions, or EGCG, for 2 hrs before lipopolysaccharides (LPS) stimulation. Cytokine secretion was assessed by ELISA. The data are the means ± standard deviations of triplicate assays for three independent experiments. *P value of < 0.05 compared with untreated control.

 

Journal of Dental Research, Vol. 85, No. 3, 235-239 (2006)
DOI: 10.1177/154405910608500306
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