Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Teng, Y.-T.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Teng, Y.-T.A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Protective and Destructive Immunity in the Periodontium: Part 1—Innate and Humoral Immunity and the Periodontium

Y.-T.A. Teng

Lab. of Molecular Microbial Immunity, Eastman Department of Dentistry, Eastman Dental Center, Box-683, 625 Elmwood Ave., and Centre for Oral Biology, Dept. of Microbiology and Immunology, School of Medicine and Dentistry, The University of Rochester Medical Center, Rochester, NY 14620, USA; andy_teng{at}urmc.rochester.edu


Figure 1
View larger version (40K):
[in this window]
[in a new window]

  		Figure. TLR signaling pathways and innate and adaptive immunity. Different TLR-dependent and -independent recognitions of the microbial components and critical TLR immediate adapters (MyD88, TIRAF, TRAM, TRIF) and cytoplasmic adapters (i.e., TRAF6, PI3K, IRAK1/2/4, etc.) in the down-stream signaling pathways of NF-{kappa}B and IRF-3 for the subsequent activation of the pro-inflammatory and inflammatory cytokines. The MyD88-dependent and -independent pathways are indicated in solid and dashed lines with arrows, respectively. PGN represents proteoglycans; note that TLR10, 11, and 12 are not described here. The resulting TLR signaling and activation of innate immunity can influence or modulate the subsequent outcomes or balance of the antigen-specific adaptive immune responses at various levels associated with Th1 vs. Th2 immunity for tissue inflammation and destruction or anti-inflammatory responses for the repair processes.

 

Journal of Dental Research, Vol. 85, No. 3, 198-208 (2006)
DOI: 10.1177/154405910608500301
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?