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Journal of Dental Research
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Articaine is More Effective than Lidocaine or Mepivacaine in Rat Sensory Nerve Conduction Block in vitro

I. Potocnik1,*, M. Tomsic2, J. Sketelj3 and F.F. Bajrovic3

1 Department of Restorative Dentistry & Endodontics, University of Ljubljana, Dental School, Hrvatski trg 6,1000 Ljubljana, Slovenia;
2 Institut Jozef Stefan, Ljubljana; and
3 Institute of Pathophysiology, Medical Faculty, University of Ljubljana


Figure 1
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  		Figure 1. Registration of the Compound Action Potential (CAP) of the isolated sural nerve (SN) in a liquid paraffin bath. Local anesthetic solution (LA) was injected into the silicone tube (ST), which had been cut longitudinally and placed between the stimulating (S) and recording (R) electrodes.

 

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  		Figure 2. The Compound Action Potential (CAP) of A-fibers (a) and C-fibers (b) of the rat sural nerve before nerve block induction. The voltage and duration (intensity) of the supramaximal electrical stimulus were about 10 V-10 µsec for the A-fiber signal and about 12 V-1 msec for the C- fiber signal.

 

Figure 3
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  		Figure 3. The amplitude of the CAPs (a) and conduction velocities (b) of rat sural nerve (mean ± SD) A-fibers before (black bars) and after (white bars) nerve block induction with 2% (n = 8) and 4% (n = 9) lidocaine (L), 3% (n = 10) mepivacaine (M), and 2% (n = 9) and 4% (n = 8) articaine (A).

 

Journal of Dental Research, Vol. 85, No. 2, 162-166 (2006)
DOI: 10.1177/154405910608500209
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