Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Goodis, H.E.
Right arrow Articles by Hargreaves, K.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goodis, H.E.
Right arrow Articles by Hargreaves, K.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Tissue pH and Temperature Regulate Pulpal Nociceptors

H.E. Goodis1,*, A. Poon2 and K.M. Hargreaves2,3

1 Division of Endodontics, Department of Preventive and Restorative Sciences, UCSF, 707 Parnasssus Ave., San Francisco, CA 94143, USA; and
2 Department of Endodontics and
3 Department of Pharmacology, UTHSCSA, San Antonio, TX, USA


Figure 1
View larger version (9K):
[in this window]
[in a new window]

  		Figure 1. Effect of administration of capsaicin to the dental pulp at a pH of 7.4 and 6.5. Capsaicin evoked a significant increase in CGRP over basal rates of release: 9.5 fmmol/2.1 mL at a pH of 6.5 and 6.5 fmol/2.1 mL at a pH of 7.4. Recovery 1, 2, and 3 indicate successive fractions after capsaicin stimulation. While fractions continued to be collected, data (not shown) dictated that levels returned to baseline.

 

Figure 2
View larger version (9K):
[in this window]
[in a new window]

  		Figure 2. Percent increase in immunoreactive CGRP (iCGRP) over basal rates at a pH of 7.4 and 6.5 and temperatures of 37°C and 26°C. There was a 140% increase in iCGRP release with CAP/pH 6.5.

 

Journal of Dental Research, Vol. 85, No. 11, 1046-1049 (2006)
DOI: 10.1177/154405910608501114
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?