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Journal of Dental Research
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The Role of Matrix Metalloproteinases (MMPs) in Human Caries

C. Chaussain-Miller1,2,*, F. Fioretti2, M. Goldberg1 and S. Menashi3

1 Groupe Matrice Extracellulaire et Biominéralisation (EA 2496) and
2 Department of Conservative Dentistry and Endodontics, Faculté de Chirurgie Dentaire, 1 rue Maurice Arnoux, 92120 Montrouge, Université Paris 5, France; and
3 Laboratoire CRRET, CNRS UMR 7149, Université Paris XII, Créteil, France


Figure 1
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  		Figure 1. Domain structure of the different MMPs (from Visse and Nagase, 2003).

 

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  		Figure 2. Progression of caries in human dentin. Magnification, 20,000X. C, cavity; B, cariogenic bacteria; LF, lysis front; H+, bacterial acids; SCD, soft carious dentin.

 

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  		Figure 3. Invasion of human dentin by cariogenic bacteria located inside enlarged tubuli. Magnification, 54,000X. ITD, intertubular dentin; PD, residual peritubular dentin; LC, lumen of the canaliculi; B, cariogenic bacteria; MMP, active MMPs.

 

Journal of Dental Research, Vol. 85, No. 1, 22-32 (2006)
DOI: 10.1177/154405910608500104
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