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Journal of Dental Research
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Suppression of Stress-induced nNOS Expression in the Rat Hypothalamus by Biting

N. Hori1, M.-C. Lee2,*, K. Sasaguri3, H. Ishii3, M. Kamei3, K. Kimoto1, M. Toyoda1 and S. Sato3

1 Oral and Maxillofacial Rehabilitation, Division of Prosthetics,
2 Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, and
3 Craniofacial Growth and Development Dentistry, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan;


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  		Figure 1. Expression of nNOS mRNA levels in the hypothalamus following the 30- and 60-minute restraint periods, with or without biting (N = 3 per group). (A) nNOS mRNA levels were increased by 30 min of restraint, and were suppressed by biting during restraint. (B) The increase of nNOS mRNA was statistically significant (*p < 0.05, ANOVA/Fisher’s PLSD). Levels in animals allowed to bite during restraint were significantly different ({dagger}p < 0.05, ANOVA/Fisher’s PLSD) from those in animals restrained without biting.

 

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  		Figure 2. Effects of restraint duration and biting on expression of nNOS-positive neurons in the right side of the paraventricular nucleus (PVN). (A) Photomicrographs of nNOS-positive neurons in the control, restraint, and restraint with biting groups. Scale bar = 500 µm. (B) The number of nNOS-positive neurons observed after restraint was significantly higher ({dagger}{dagger}p < 0.01, ANOVA/Fisher’s PLSD) than that observed in controls. nNOS-positive neurons were significantly reduced (**p < 0.01, ANOVA/Fisher’s PLSD) by biting during the 30- and 60-minute restraint periods (N = 6 per group). Values given are means ± SEM of nNOS-positive neurons in the PVN.

 

Journal of Dental Research, Vol. 84, No. 7, 624-628 (2005)
DOI: 10.1177/154405910508400708
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