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Journal of Dental Research
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Genome-wide Linkage Analysis of Mandibular Prognathism in Korean and Japanese Patients

T. Yamaguchi1,2, S.B. Park3, A. Narita2, K. Maki1 and I. Inoue2,*

1 Department of Orthodontics, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Outa-ku, Tokyo, 145-8515, Japan;
2 Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan; and
3 Department of Orthodontics, Pusan National University, 1-10, Ami-dong, Seo-gu, Pusan, 602-739, Korea;


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  		Figure 1. Genome-wide linkage study of MP with 90 affected sibling-pairs. Zlr scores that were computed by the GENEHUNTER-PLUS across all the chromosomes for 405 markers genotyped with 90 sibships comprised of 40 sibling-pairs of Koreans and 50 sibling-pairs of Japanese were demonstrated. The linkage results of Korean (yellow line), Japanese (purple line), and combined (blue line) sibling-pairs are shown. Chromosome number is designated at the top of each plot. The distance from the p-terminus is shown (in cM) in the bottom.

 

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  		Figure 2. High-resolution mapping of chromosome 1. Thirty-one markers were added to the framework mapping set, and the high-resolution mapping with 62 markers was performed on chromosome 1. The markers used in the study are shown at the bottom. The linkage results of Korean (yellow line), Japanese (purple line), and combined (blue line) sibling-pairs are shown.

 

Journal of Dental Research, Vol. 84, No. 3, 255-259 (2005)
DOI: 10.1177/154405910508400309
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