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Journal of Dental Research
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Potential Modern Alternative Designs for Caries Clinical Trials (CCTs) and How These can be Validated against the Conventional Model

R.K. Chesters1,*, R.P. Ellwood2, A.R. Biesbrock3 and S.R. Smith4

1 Unilever Dental Research, Port Sunlight, Bebington, UK;
2 Colgate Palmolive, Dental Health Unit, Manchester, UK;
3 Procter & Gamble Co., Cincinnati, OH, USA; and
4 GlaxoSmithKline, Weybridge, UK;


Figure 1
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  		Figure 1. Cross-sectional caries prevalence (DMFT) in 1983 and 1993 for children in areas of the United Kingdom with different caries attack rates. Data taken from National Surveys (O’Brien, 1994; Todd and Dodd, 1985)

 

Figure 2
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  		Figure 2. Cell size as a function of predicted caries increment for control group. (Data supplied by Unilever Dental Research.)

 

Figure 3
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  		Figure 3. Predicted two-year caries increment (DMFT) for different ages at baseline, derived from cross-sectional data.

 

Figure 4
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  		Figure 4. Fluoride dose response. Shows caries increments in three- or four-year clinical trials comparing similar toothpastes with different fluoride levels (Clarkson et al., 1993).

 

Journal of Dental Research, Vol. 83, No. suppl 1, C122-C124 (2004)
DOI: 10.1177/154405910408301S26
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