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Journal of Dental Research
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Identification of RANKL in Osteolytic Lesions of the Facial Skeleton

J.Y.Y. Tay1,*, B.H. Bay2, J.F Yeo3, M. Harris4, S. Meghji5 and S.T. Dheen2

1 Dept. of Oral and Maxillofacial Surgery, National Dental Centre, 5 Second Hospital Avenue, S168938, Singapore;
2 Dept. of Anatomy, National University of Singapore;
3 Dept. of Oral and Maxillofacial Surgery, National University of Singapore;
4 Dept. of Oral and Maxillofacial Surgery, St Bartholomew’s and the Royal London School of Medicine and Dentistry, United Kingdom; and
5 Eastman Institute of Oral Science, UK;


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  		Figure 1. Positive RANKL-immunoreactivity in stromal cells of ameloblastoma (A), dentigerous cyst (B), odontogenic cyst (C), and radicular cyst (D). Giant cell granuloma served as positive control (E), while the fibro-epithelial polyp served as negative control (F). Positive cells seen in the fibro-epithelial polyp are dendritic cells which are known to express RANKL. Endothelial cells in blood vessels supplying the osteolytic lesions also show positive staining to RANKL (G).

 

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  		Figure 2. Positive TRAP-immunoreactivity in stromal cells of ameloblastoma (A), dentigerous cyst (B), odontogenic cyst (C), and radicular cyst (D). Giant cell granuloma served as positive control (E), while the fibro-epithelial polyp served as negative control (F). TRAP-positive cells are recruited from blood vessels supplying the osteolytic lesions (G). Multinucleation of pre-osteoclasts to mature osteoclasts is demonstrated by immunofluorescence (H). Nuclei are stained red by propidium iodide, and TRAP-positive cells are stained green. In situ hybridization showing positive staining for human calcitonin receptor in two multi-nucleated cells (I) and a negatively stained control (J).

 

Journal of Dental Research, Vol. 83, No. 4, 349-353 (2004)
DOI: 10.1177/154405910408300415
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