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Journal of Dental Research
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The Induction of Gene Mutations and Micronuclei by Oxiranes and Siloranes in Mammalian Cells in vitro

H. Schweikl1,*, G. Schmalz1 and W. Weinmann2

1 Department of Operative Dentistry and Periodontology, University of Regensburg, D-93042 Regensburg, Germany; and
2 3M ESPE AG, D-82229 Seefeld, Germany;


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  		Figure 1. Chemical structures of oxiranes and siloranes.

 

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  		Figure 2. Induction of micronuclei in V79 cells after a four-hour exposure to oxiranes and siloranes. The numbers of micronuclei were determined in three replicate cultures per concentration (mean ± SD) in the presence (+) and absence (–) of a homogenate from rat liver (S9). Each compound was tested at least in two independent experiments, and data from one representative experiment are presented.

 

Journal of Dental Research, Vol. 83, No. 1, 17-21 (2004)
DOI: 10.1177/154405910408300104
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