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Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement

Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;

View larger version (15K): [in this window] [in a new window]   Figure 1. Bone resorption triggered by various agents is sensitive to inhibition by the matrix metalloproteinase inhibitor 44463, but not its ineffective stereo-isomer, 44201. The data are expressed as the mean ± SE (n = 4). The asterisk indicates p < 0.05 using Student’s t test.

View larger version (74K): [in this window] [in a new window]   Figure 2. Pre-coating dentin slices with a short RGD-containing peptide rescues bone resorption by mouse marrow from inhibition by the matrix metalloproteinase inhibitor 44463. Mouse marrow osteoclasts were grown in the presence of 10 nM calcitriol for 6 days. Dentin slices were coated with either an RGD-containing peptide or vehicle as described in MATERIALS & METHODS. The marrow cultures were loaded onto the coated or uncoated dentin slices in the presence of the matrix metalloproteinase inhibitor 44463 or its ineffective stereo-isomer, 44201. After 5 days, the dentin slices were prepared for scanning electron microscopy. (A) The bar graph presents quantitative analysis of the experiment. The data are expressed as the mean ± SE (n = 4). The asterisk indicates p < 0.05 using Student’s t test. (B–E) Representative electron micrographs from the experiment described above. (B) Uncoated dentin slice, control inactive MMPI; (C) uncoated dentin slice, plus active MMPI; (D) RGDcoated dentin slice, inactive MMPI; and (E) RGD-coated dentin slice, active MMPI. The size bar for B–E equals 25 µM.

View larger version (16K): [in this window] [in a new window]   Figure 3. Tooth movement kinetics in the control or Ilomastat-treated rats. Each point represents the mean ± SEM of 5–7 animals. A one-way analysis of variance (ANOVA) was used for testing the significance between the groups. *p < 0.01.

Journal of Dental Research, Vol. 82, No. 9, 687-691 (2003)
DOI: 10.1177/154405910308200906


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