Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Onozuka, M.
Right arrow Articles by Saito, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onozuka, M.
Right arrow Articles by Saito, S.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*MRI Scans
*Seniors' Health
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Age-related Changes in Brain Regional Activity during Chewing: A Functional Magnetic Resonance Imaging Study

M. Onozuka1,*, M. Fujita1, K. Watanabe2, Y. Hirano3, M. Niwa4, K. Nishiyama5 and S. Saito6

1 Departments of Anatomy and Basic Neuroscience and
2 Physiology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan;
3 Department of Veterinary Physiology, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan;
4 Department of Radiology, Yoro Central Hospital, Yoro 503-0013, Japan;
5 Department of Oral Biochemistry, Kanagawa Dental College, Yokosuka 238-8580, Japan; and
6 Business Center for Academic Societies of Japan, Tokyo 113-8622, Japan;


Figure 1
View larger version (102K):
[in this window]
[in a new window]

  		Figure. Effect of aging on brain regional activity during chewing. (A) The task paradigm used. (B,C,D) Significant signal increases associated with gum-chewing in a young adult subject (B), a middle-aged subject (C), and an aged subject (D). Upper section: Activated areas superimposed on a template (p < 0.05, corrected for multiple comparisons). Lower section: Activated regions superimposed on a T1 weighted MRI (p < 0.001, uncorrected for multiple comparisons). Abbreviations: smc, primary sensorimotor cortex; sma, supplementary motor area; i, insula; t, thalamus; c, cerebellum; pfa, prefrontal area. Arrowheads: Activated regions in the parietal, temporal, or occipital association cortices. Color scale: t value (degrees of freedom = 87.12). (E) Percentage increase in the fMRI signal in the young adult (Y, n = 10), middle-aged (M, n = 8), and aged (A, n = 10) groups. Each column represents the mean ± SE. *p < 0.05 compared with young adults. **p < 0.0001 compared with young adults.

 

Journal of Dental Research, Vol. 82, No. 8, 657-660 (2003)
DOI: 10.1177/154405910308200817
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?