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Journal of Dental Research
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Correlations of the Expression of Fibroblast Growth Factor-2, Vascular Endothelial Growth Factor, and their Receptors with Angiogenesis in Synovial Tissues from Patients with Internal Derangement of the Temporomandibular Joint

J. Sato*, N. Segami, Y. Yoshitake1 and K. Nishikawa1

Department of Oral and Maxillofacial Surgery and
1 Department of Biochemistry, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan;


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  		Figure 1. Immunohistochemical overview for FGF-2, FGFR-1, VEGF, Flt-1, and CD34 of the synovial tissues. (A) FGF-2-stained sections obtained from a patient with internal derangement (insert, low power). (B) FGFR-1-stained sections obtained from the same patient (insert, low power). (C) VEGF-stained sections obtained from the same patient (insert, low power). Immunoreactivities for FGF-2, FGFR-1, and VEGF are observed in the synovial lining cells (large arrows), endothelial cells of the blood vessels (arrowheads), and fibroblasts (small arrows). (D) Flt-1-stained sections obtained from the same patient (insert, low power). Immunoreactivities for Flt-1 are observed in the endothelial cells of the blood vessels (arrowheads) and synovial lining cells (large arrows). (E) A specimen obtained from the same patient incubated with CD34 antibody (insert, low power). Beneath the synovial lining cells, lumen structures of various sizes are immuno-positive, making them easy to distinguish from other cells. (F) FGF-2-stained sections obtained from a control patient. Only a few immuno-positive cells were observed in the synovial lining cells (arrows). (G) FGFR-1, (H) VEGF, and (I) Flt-1-stained sections obtained from a control patient. No immunoreactivities are observed in the synovial tissue. (J) A control specimen incubated with CD34 antibody showing only a few immunopositive cells (arrows) (bar, 50 µm).

 

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  		Figure 2. Correlation between the percentage of immuno-positive cells and microvessel density. (A) (FGF-2) No significant correlation is observed by Spearman rank correlation coefficient (p = 0.13, r = 0.23). (B) FGFR-1, (C) VEGF, (D) Flt-1. A significant correlation is observed (FGFR-1, p = 0.025, r = 0.34; VEGF, p = 0.0003, r = 0.53; Flt-1, p < 0.0001, r = 0.68).

 

Journal of Dental Research, Vol. 82, No. 4, 272-277 (2003)
DOI: 10.1177/154405910308200406
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